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KMID : 0861020060210020189
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Korea Journal of Herbology
2006 Volume.21 No. 2 p.189 ~ p.195
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Anti-inflammatory effect of extract of Asarum sieboldii in LPS-stimulated Murine peritoneal macrophage
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Jung Won-Seok
Yoo Hyeon-Mi
Seo Sang-Wan
Cho Joon-Ki
Son Ji-Woo
Park Min-Cheol
Choi Chang-Min
Yeom Seung-Ryong
Hwang Sang-Wook
Kim Yong-Woo
Song Dal-Soo
Kim Yeong-Mok
Shin Min
Song Ho-Joon
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Abstract
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Objectives: The purpose of this study was to investigate the anti-inflammatory effects of extract Asarum sieboldii(AS) on the peritoneal macrophage.
Methods: To evaluate of anti-inflammatory of AS, we examined cytokines production in lipopolysacchride (LPS)-induced macrophages. Furthermore, we checked molecular mechanism using western blot.
Results: 1. Extract from AS reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2. Extract from AS itself does not have any cytotoxic effect. AS inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase B a (IkBa) in the LPS-stimulated peritoneal macrophages
Conclusions: AS down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of AS
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KEYWORD
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Asarum sieboldii(AS), lipopolysaccharide (LPS), inflammation
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